Thankfully, they’d transition from irrational phobias to elevated anxieties about going into high school and my future. Throughout middle school I’d find myself kept up at night due to paranoia leftover from my childhood. I spent much of my secondary education entangled in my emotions. It’s that truth - and the truth of Omori’s story - that shatters your heart and shatters the leftover shards, leaving your friends to pick up the pieces but ultimately leaving you to put yourself back together. The frame-by-frame differences breathe life into the game, as change is a vital part of life. There is never a still moment in the game, with cutscenes, sprites, backgrounds, battles and characters in constant animation. Omori’s friends are the most engaging, the game’s length giving you a wealth of adorable interactions that flesh out how much they care for each other. Together, they fight and befriend the most colorful of characters. Omori can be manipulated by the player to emotional depths that his friends cannot reach, giving him the potential to be more powerful or more vulnerable than any of his other friends. The characters’ expressiveness is an extension of the game itself, the main fights operating on a rock-paper-scissors system of the emotions of characters and enemies: happy beats angry, angry beats sad, sad beats happy. They quest to save their bashful best friend Basil, helped along from the sidelines by Omori’s older sister, Mari. You play as Omori, a comically stoic child as he adventures with his much-more expressive friends: hard-headed Aubrey, enthusiastic Kel and his gentle older brother, Hero. Wholesome hand-drawn art, pretty pixelated visuals and facetious Photoshops all mix together to create the wondrous, dreamlike world you play through. The RPG “OMORI” opens with the following message upon booting up: “This game contains depictions of depression, anxiety, suicide, and may not be suitable for all audiences.” Despite this warning, at first glance the game seems like a cheery, fun-filled romp. It was at this point I found friends with similar backgrounds & interests - video games being a focal point. The end result left me as a primary schooler refusing a solitary bedroom until middle school. Real life was where my numerous childhood fears sprouted: fear of the dark, heights, bugs, open water, the supernatural. In my somewhat lonely childhood - a combination of overprotective immigrant parents, a somewhat childless neighborhood on the edge of town and my cultural disconnection being a Desi student in a school of white kids - I sought these immersions as escapes from a duller and disconnected reality. As a kid, I fell into a variety of deeply engrossing media, but video games would remain the most immersive. It’s a medium I find more engaging than any other - the audiovisual stimulation of videos and music mix with an interactive story, allowing you to insert yourself into a narrative shaped by your actions. Video games have always been an escape for me. If you empathize with any of what has been discussed in this piece, I would urge you to please use whatever resources are available to you to get the help you need. Everything I have discussed is material I’m comfortable publishing because I have extensively unpacked it while getting the professional help I needed in therapy. Likewise, many details of my disorders were withheld for the sake of my privacy. Our work justifies targeting the Hippo-TAZ pathway as a therapy for human BLBC, and our mouse model represents a powerful tool for evaluating candidate agents.Content Warning: Discussions of anxiety and depressionĪuthor’s Note: Many details of the plot of “OMORI” were withheld for the sake of preserving the impact of its story. Addition of Trp53 deficiency to our Mob1a/b-deficient mouse model enhanced tumor grade and accelerated cancer progression. TP53 mutation is rare in human precancerous BLBC but frequent in invasive BLBC. In a human estrogen receptor + luminal breast cancer cell line, TAZ hyperactivation skewed the features of these luminal cells to the basal phenotype, consistent with the aberrant TAZ activation frequently observed in human precancerous BLBC lesions. In situ early-stage BLBC-like malignancies developed in mutant animals by 2 wk of age, and invasive BLBC appeared by 4 wk. Deletion of Mob1a/b in mouse mammary luminal epithelium induced rapid and highly reproducible mammary tumorigenesis that was dependent on TAZ but not yes-associated protein 1 (YAP1). Here, we present data suggesting that the Hippo–transcriptional coactivator with PDZ-binding motif (TAZ) pathway is a key driver of BLBC onset and progression. Basal-like breast cancer (BLBC) is the most aggressive form of this disease, and patients have a poor prognosis. Breast cancer is the most frequent malignancy in women worldwide.
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